Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

9-year-old female presenting with l lower leg pain diagnosed with erdheim-chester disease (ECD)

View Full Paper
Ask AI
Bookmark
Share

Authors

JZJessica ZonJWJason WhiteNANataly Apollonsky

Discussion

Loading...

Member takes

Overview

Case report reveals complete metabolic response in a pediatric patient with Erdheim-Chester disease after dabrafenib and tocilizumab treatment.

Key Points

  • To highlight the presentation and treatment response of Erdheim-Chester disease in a pediatric patient.
  • Retrospective review of electronic medical records
  • Assessment included imaging and pathology from bone biopsy
  • Cytokine panel analysis and treatment with tocilizumab and dabrafenib
  • Patient presented with left lower leg pain and radiolucent lesions
  • Pathology confirmed non-Langerhans histiocytosis
  • PET CT after treatment showed complete metabolic response of bony lesions
  • Patient exhibited excellent tolerance to dabrafenib with minimal side effects

Cite This Study

Zon et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6afhttps://doi.org/10.1182/blood-2025-7334
View Full Paper
Ask AI
Bookmark
Share