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December 8, 2025BloodOpen Access

Liver-targeted delivery of bioengineered induced tregs via nanoparticles prevents and treats acute gvhd

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Authors

HHHyesun HyunMSMathew SebastianAWAndrew Z. Wang

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Overview

Bioengineered iTregs improve survival and lower GvHD symptoms in mice, suggesting new treatments for autoimmunity.

Key Points

  • Evaluate the efficacy of liver-targeted delivery of iTregs using nanoparticles in managing graft-versus-host disease.
  • Developed bioorthogonal click chemistry platform with lipid-coated nanoparticles for iTreg delivery.
  • Conducted adoptive transfer of DBCO-iTregs in murine models of bone marrow transplantation.
  • Administered ALPA NPs before and after transplantation to assess efficacy in preventing and treating GvHD.
  • Liver-targeted DBCO-iTregs significantly improved survival rates and reduced clinical GvHD scores.
  • Enhanced hepatic localization of iTregs was achieved through nanoparticle-mediated delivery.
  • Reduced serum levels of IFN-γ and improved phenotypic stability of iTregs were observed.

Cite This Study

Hyun et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6cchttps://doi.org/10.1182/blood-2025-5861
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