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December 8, 2025Blood

AML blasts and monocytic myeloid-derived suppressor cells (M-MDSC) inhibit human mucosal-associated invariant t (MAIT) cells activation.

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Authors

CCCharlotte CalvoEDElise Diaz

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Overview

Experiments demonstrate myeloid-derived suppressor cells inhibit T-cell activation in MAIT cells, suggesting clinical consequences for cancer immunotherapy.

Key Points

  • This study investigates the effects of AML blasts and monocytic MDSCs on the activation of MAIT cells and their potential anti-tumor role.
  • Co-culture of PBMCs, sorted T lymphocytes, monocytes, and MAIT cells from healthy donors with AML cell lines or M-MDSCs.
  • Assessment of MAIT cell activation through activation markers and transcriptomic analyses.
  • Exploration of TCR-dependent and TCR-independent stimulation effects on MAIT cells.
  • MAIT cells showed cytotoxicity against AML cell lines upon activation by cytokines IL-12 and IL-18.
  • AML blasts inhibited both TCR-dependent and TCR-independent MAIT cell activation via unknown mechanisms.
  • Transcriptomic analyses indicated signs of T-cell exhaustion in MAIT cells co-cultured with AML blasts.

Cite This Study

Calvo et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6e2https://doi.org/10.1182/blood-2025-5860
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