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December 8, 2025Blood

Outcomes of stem cell transplantation in pediatric and adolescent/young adult patients with trisomy 21: A single-center experience

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Authors

OOOlayinka OkelejiPTPriti Tewari

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Overview

Retrospective review finds HSCT improved survival in young patients with Down Syndrome and acute leukemia, despite comorbidities.

Key Points

  • Evaluate outcomes of stem cell transplantation in pediatric and young adult patients with Down Syndrome and acute leukemia.
  • Retrospective chart review of 3 AYA patients with T21 who underwent HSCT for relapsed acute leukemia
  • Assessment of peri-transplant course, graft-vs-host disease, and transplant-related toxicities
  • Overall survival improves with HSCT in patients with Down Syndrome and acute leukemia
  • Two of the three patients remain alive after HSCT, indicating potential benefits
  • Toxicities including viral reactivation and mucositis were observed but managed effectively

Cite This Study

Okeleji et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d734https://doi.org/10.1182/blood-2025-7742
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improving outcomes of hematopoietic stem cell transplant for leukemia in children and young adults in resource-limited setting2024 · 4 citations
  2. 2Allogeneic hematopoietic stem cell transplantation outcomes in pediatric patients with refractory acute myeloid leukemia2024
  3. 3Allogeneic Hematopoietic Stem Cell Transplantation in Adolescents and Young Adults With Acute Lymphoblastic Leukemia-A Retrospective, Dual-Center Study.2025 · 1 citations
  4. 4Transplantation outcomes in patients with Down syndrome‐associated acute lymphoblastic leukaemia: Implications for treatment intensity and the use of novel therapies2026
  5. 5Excellent Outcomes of Hematopoietic Stem Cell Transplant for Pediatric High Risk and Relapsed Acute Myeloid Leukemia–A Decade Long Experience From Developing Nation2025