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December 8, 2025BloodOpen Access

Ribosome biogenesis and its regulation by the exportin, CSE1L, are targetable vulnerabilities in childhood and young adult Acute Myeloid Leukemia

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Authors

ACAli CheginiUniversity Health NetworkCSChaitra SarathyFHFieke W. HoffNational Institutes of Health

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Implication

Analysis reveals CSE1L's role in ribosome biogenesis and nucleocytoplasmic transport in young AML, suggesting new therapeutic targets.

Key Points

  • Investigating the role of CSE1L in childhood and young adult acute myeloid leukemia related to ribosome biogenesis.
  • Identified nucleocytoplasmic transport pathway enrichment in young vs older AML patients.
  • Utilized shRNA and CRISPR knockout techniques to examine CSE1L function in AML cell lines.
  • Analyzed gene expression and ribosomal protein interactions through BioID and proximity ligation assay.
  • CSE1L depletion led to reduced AML viability and impaired leukemic engraftment.
  • Young AML cells exhibited increased sensitivity to RNA polymerase I inhibitors like BMH-21.
  • Ribosome biogenesis pathways were the most abundantly expressed in young AML samples.

Cite This Study

Chegini et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d785https://doi.org/10.1182/blood-2025-1452
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune Dysregulation and State-Transition Transcriptomic Signatures Underlying Pediatric Chronic Myeloid Leukemia Pathogenesis2025
  2. 2Regulation of ribosomal RNA synthesis in Acute Myeloid Leukemia2025
  3. 3Abstract 1365: Regulation of ribosomal RNA synthesis in acute myeloid leukemia.2026
  4. 4Single-cell transcriptomic analysis reveals impaired immune profiles in elderly AML patients2025
  5. 5From infancy to young adulthood: Exploring the divergent genomic mechanisms that drive AML.2026