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December 8, 2025BloodOpen Access

Single-cell transcriptomic analysis reveals impaired immune profiles in elderly AML patients

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Authors

YPYebo PengCapital Medical UniversityYHYingying HuoShanghai Jiao Tong UniversityWGWen GaoMinistry of Education of the People's Republic of China

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Implication

Single-cell transcriptomic analysis reveals impaired immune profiles in elderly AML patients, indicating the role of immunosenescence in therapy response.

Key Points

  • This study aims to explore the immune cell profiles and senescence in elderly AML patients compared to younger counterparts.
  • Analyzed scRNA-seq data from 63 bone marrow samples categorized into young and elderly AML patients and controls.
  • Identified leukemic cells using a random forest model and categorized cell types using a reference-based method.
  • Compared immune cell proportions and activity of transcription factors between elderly AML patients and other groups.
  • Elderly AML patients showed lower immune cell proportions compared to healthy controls.
  • A significant increase in CD8+ T cells and TEMRA cells was observed in elderly AML, indicating immune senescence.
  • FOXO1 activity was lower in elderly AML compared to younger patients, suggesting reduced immune function.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d22ehttps://doi.org/10.1182/blood-2025-1409
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrative clinical and molecular analysis of outcome in elderly African ancestry Acute Myeloid Leukemia2025
  2. 2Age-associated non-mutational resistance in acute myeloid leukemia is driven by DNA damage-induced transcriptional heterogeneity2025
  3. 3Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia2025
  4. 4Comprehensive profiling of the bone marrow microenvironment reveals an exhausted immune signature associated with tumor burden in Acute Myeloid Leukemia2025
  5. 5Abstract LB227: Accelerated intra-clonal transcriptomic diversification of hematopoietic stem cells during aging fuels leukemia evolution2024 · 1 citations