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December 8, 2025BloodOpen Access

Comprehensive profiling of the bone marrow microenvironment reveals an exhausted immune signature associated with tumor burden in Acute Myeloid Leukemia

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Authors

GCGabriella ChirumboloUniversity of BolognaGTGiusy TespioIstituto Oncologico RomagnoloFZFederico ZingarelliIstituto di Ematologia di Bologna

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Implication

Comprehensive profiling reveals immune evasion and immune checkpoint dynamics in AML patients, suggesting targets for therapy.

Key Points

  • This research aims to profile the bone marrow immune microenvironment in acute myeloid leukemia and its relationship with tumor burden.
  • Analyzed bone marrow samples from 38 AML patients and 9 healthy donors using multiparametric flow cytometry.
  • Assessed key immune cell populations and their expressions of immune checkpoints.
  • Conducted longitudinal analysis in 4 refractory AML patients after treatment.
  • AML patients showed increased naïve CD4+ and CD8+ T cells, alongside higher proportions of CD8 effector T cells.
  • Immune checkpoints such as TIM1, CD244, and TIGIT were upregulated on immune cells in AML.
  • AML tumor burden correlated with higher exhaustion-related immune checkpoint expressions.

Cite This Study

Chirumbolo et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e574https://doi.org/10.1182/blood-2025-3517
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrative analysis of the interplay between peripheral immune landscape and leukemic blast adaptation in Acute Myeloid Leukemia2025
  2. 2Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia2025
  3. 3Leukocyte immunoglobulin-like receptor subfamily B member 1 expression defines CD8+ T cell exhaustion in acute myeloid leukemia2026
  4. 4The Acute Myeloid Leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function2025
  5. 5Abstract 6869: Paired single-cell B-cell transcriptomics and receptor sequencing reveal activation states and clonal signatures that characterize B cell immunity in acute myeloid leukemia2024