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December 8, 2025Blood

Integrative analysis of the interplay between peripheral immune landscape and leukemic blast adaptation in Acute Myeloid Leukemia

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Authors

ECEla CerovskáCharles UniversityDKDávid KundrátInstitute of Haematology and Blood TransfusionPSPavla SuchánkováInstitute of Haematology and Blood Transfusion

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Overview

Comprehensive profiling of immune landscape correlates with clinical outcomes in AML, highlighting immune evasion and potential biomarkers.

Key Points

  • The research aims to profile the peripheral blood immune landscape in AML and its correlation with clinical outcomes.
  • Peripheral blood samples collected from 32 patients with non-acute promyelocytic AML
  • Cell profiling performed using digital cytometry and targeted sequencing
  • Gene expression analyzed using bioinformatics tools like StringTie2 and R
  • Complete remission was associated with higher fractions of CD8⁺ T cells and resting NK cells
  • Significant differences in lymphoid cytotoxic cell fractions between responders and non-responders
  • Differentially expressed genes in leukemic blasts correlated with immune pressure and clinical response

Cite This Study

Cerovská et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da0fhttps://doi.org/10.1182/blood-2025-3486
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