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December 8, 2025BloodOpen Access

Functional plasma cell signatures mark AML chemotherapy responders: Evidence from immune niche profiling

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Authors

MYMa YingCGClaire GouldDTDiana O. Treaba

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Overview

Analysis shows differential gene expression in leukemic stem cells within the bone marrow microenvironment, indicating immune response differences in AML.

Key Points

  • This research investigates the role of plasma cell signatures in distinguishing chemotherapy responders in acute myeloid leukemia (AML).
  • Utilized RNA-sequencing and spatial transcriptomics on bone marrow biopsies and aspirates.
  • Examined immune microenvironment through bulk RNA sequencing at diagnosis and post-chemotherapy.
  • Employed CIBERSORT for deconvolution of immune populations in AML samples.
  • Identified few immune cell type differences between non-responders and responders post-chemotherapy.
  • Notable differences in B cell populations, with responders showing increased plasma cells and class-switched immunoglobulin genes.
  • Differential gene expression analysis revealed enrichment of B cell progenitors in non-responders.

Cite This Study

Ying et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da3chttps://doi.org/10.1182/blood-2025-3502
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia2025
  2. 2Longitudinal single-cell spatial proteomics reveals predictive immune and stem cell signatures in Relapsed/Refractory AML2025
  3. 3Integrative analysis of the interplay between peripheral immune landscape and leukemic blast adaptation in Acute Myeloid Leukemia2025
  4. 4Abstract P08: 10x spatial transcriptomics of human AML core bone marrow biopsies reveals the complex remodeling of the non-hematopoietic stromal microenvironment post-treatment2024
  5. 5Abstract 6869: Paired single-cell B-cell transcriptomics and receptor sequencing reveal activation states and clonal signatures that characterize B cell immunity in acute myeloid leukemia2024