What question did this study set out to answer?

This research aims to understand the role of the bone marrow microenvironment in NPM1-mutant acute myeloid leukemia.

December 8, 2025Blood

Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia

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This research aims to understand the role of the bone marrow microenvironment in NPM1-mutant acute myeloid leukemia.
Utilized a 60-plex antibody panel for CODEX microscopy of BM biopsies.
Conducted high-throughput analysis of 45 NPM1-mutant AML patients and 39 matched normal controls.
Employed spatial transcriptomics with MERFISH on selected cases.
Combined machine-learning approaches for cell type identification and spatial analysis.
Identified 35 healthy and 10 leukemic cell subtypes in the bone marrow microenvironment.
Revealed significant loss of structural organization in leukemic BMME, impacting treatment response.
Characterized leukemia-specific neighborhoods with poor clinical outcomes and immune cell infiltration.

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Implication

Spatial multiomics reveals immune responses and biomarkers in the bone marrow microenvironment of NPM1-mutant AML patients, suggesting key treatment insights.

Cite This Study

Zeis et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d983 https://doi.org/10.1182/blood-2025-2572

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Implication

Spatial multiomics reveals immune responses and biomarkers in the bone marrow microenvironment of NPM1-mutant AML patients, suggesting key treatment insights.

Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia

Key Points

Discussion

Implication

Cite This Study

Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia

Key Points

Discussion

Implication

Cite This Study

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