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December 8, 2025BloodOpen Access

Deciphering the bone marrow inflammatory cytokine network in AML prognosis and immune evasion: A focus on the IL-1A-CCL3/4 axis as a novel therapeutic target

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Authors

JLJian Li

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Overview

Analysis reveals inflammatory cytokines influence immune escape and prognosis in AML, indicating potential therapeutic targets.

Key Points

  • To characterize the roles of inflammatory cytokines in AML and identify their prognostic value and mechanistic functions.
  • Profiling 20 inflammatory cytokines in bone marrow of 46 AML patients and 20 healthy controls
  • Conducting single-cell RNA sequencing to evaluate cellular sources and cytotoxic interactions
  • Assessing clinical correlations using multivariate Cox regression and ROC analysis
  • Identified 7 dysregulated inflammatory cytokines in AML with 5 linked to 5-year OS.
  • IL-1A was an independent adverse prognostic factor affecting T cell functions.
  • CCL4 expression was significantly reduced in AML patients, impairing immune response.

Cite This Study

Jian Li (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d78chttps://doi.org/10.1182/blood-2025-1456
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Also Consider

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  1. 1Comprehensive profiling of the bone marrow microenvironment reveals an exhausted immune signature associated with tumor burden in Acute Myeloid Leukemia2025
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  3. 3Allograft inflammatory factor -1 is essential for acute monocytic leukemia infiltration2025 · 1 citations
  4. 4IL-1 signaling and inflammasomes in acute myeloid leukemia: mechanisms and therapeutic opportunities2025 · 4 citations
  5. 5Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia2026