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December 8, 2025BloodOpen Access

Treatment landscape and outcome of myeloproliferative neoplasms in asia: Interim analysis of the Asian myeloproliferative neoplasm registry

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Authors

VLVivian LiUniversity of Maryland, BaltimoreQZQi ZhangTengzhou Central People's HospitalPCPaul K.S. ChanChinese University of Hong Kong

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Implication

Multicenter analysis reveals treatment benefits for myeloproliferative neoplasms in Asia, indicating improved survival with pegylated-interferon alfa.

Key Points

  • The aim is to define characteristics and outcomes of myeloproliferative neoplasms in Asia.
  • Multicenter retrospective and prospective cohort analysis
  • Survival analyzed using Kaplan-Meir method, log-rank test, and multivariate Cox-proportional hazard model
  • Propensity score matching utilized for evaluating treatment impacts
  • 130 patients progressed to secondary myelofibrosis after a median of 15.1 years
  • PEG-IFNa associated with improved overall survival in polycythemia vera and essential thrombocythemia
  • Survival rates reported for MPN subtypes: PV 24.8 years, ET 22.3 years, pre-PMF 14.7 years.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d790https://doi.org/10.1182/blood-2025-2041
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of pegylated interferon alfa-2b in myeloproliferative neoplasms: A multicenter retrospective study of 210 patients2025
  2. 2Highlights from MPN Asia 2025: Advances in Molecular Pathogenesis and Therapeutic Strategies in Myeloproliferative Neoplasms2025 · 4 citations
  3. 3Real‐world treatment patterns and outcomes in accelerated and blast‐phase myeloproliferative neoplasms: Insights from a large multi‐centre cohort analysis in the United Kingdom2026 · 1 citations
  4. 4Interferon alfa treatment of early primary myelofibrosis is associated with improved overall survival2025
  5. 5[A new era in the treatment of myeloproliferative neoplasms].2025