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December 8, 2025BloodOpen Access

Quality of life in multiple myeloma: A scoping review

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Authors

AXAoshuang XuHYHan YanQLQun Li

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Overview

Scoping review assesses quality of life outcomes in multiple myeloma treatments, suggesting key therapy implications.

Key Points

  • This review aims to synthesize quality of life changes in multiple myeloma patients receiving various treatments.
  • Conducted a global literature search in PubMed, Embase, and Cochrane Library.
  • Included trials and real-world studies assessing quality of life using the EORTC QLQ-C30 scale.
  • Narratively synthesized mean changes in quality of life scores across follow-up intervals.
  • Eight randomized controlled trials for newly diagnosed MM showed varying trends in quality of life scores.
  • Daratumumab and proteasome inhibitor combinations generally maintained stable quality of life in relapsed/refractory patients.
  • Ixazomib provided consistent long-term quality of life stability in frail patients.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7dchttps://doi.org/10.1182/blood-2025-2807
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