What type of study is this?

This is a Human Clinical Trial study.

What question did this study set out to answer?

To analyze the incidence and characteristics of infections in patients with relapsed/refractory multiple myeloma treated with bispecific antibodies and assess the role of immunoglobulin replacement.

December 8, 2025BloodOpen Access

Burden and characteristics of infections in patients treated with bispecific antibodies and the impact of immunoglobulin replacement

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Authors

EKEfstathios KastritisNational and Kapodistrian University of Athens FTFoteini TheodorakakouNational and Kapodistrian University of Athens MMMagdalini MigkouKorea University

Discussion

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Implication

Analysis reveals infection risk in multiple myeloma patients treated with bispecific antibodies, suggesting immunoglobulin replacement can reduce infections.

Key Points

To analyze the incidence and characteristics of infections in patients with relapsed/refractory multiple myeloma treated with bispecific antibodies and assess the role of immunoglobulin replacement.
Retrospective analysis of 108 patients with RRMM treated with bispecific antibodies.
Infection data collected prospectively during treatment courses.
Assessment of prophylaxis strategies, including immunoglobulin replacement and monitoring for infections.
At least one infection occurred in 65.7% of patients; cumulative infection risk was 71% by 9 months.
Infections were primarily respiratory (upper 26%, lower 27%) and had a median time to first infection of 81 days.
Prophylactic immunoglobulin reduced the incidence of infections significantly, especially grade 2 infections.

Cite This Study

Kastritis et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7e2 https://doi.org/10.1182/blood-2025-2227

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Implication

Analysis reveals infection risk in multiple myeloma patients treated with bispecific antibodies, suggesting immunoglobulin replacement can reduce infections.

Burden and characteristics of infections in patients treated with bispecific antibodies and the impact of immunoglobulin replacement

Discussion

Member takes

Implication

Key Points

Cite This Study

Burden and characteristics of infections in patients treated with bispecific antibodies and the impact of immunoglobulin replacement

Discussion

Member takes

Implication

Key Points

Cite This Study

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