Observational study finds cumulative incidence of second primary malignancies is 8.8% at 5 years for multiple myeloma patients, suggesting genetic and environmental influences.
Key Points
To estimate the cumulative incidence of second primary malignancies in multiple myeloma patients and identify associated risk factors.
Retrospective cohort study of patients with multiple myeloma at a cancer center.
Estimated cumulative incidence of second primary malignancies using Kaplan-Meier method.
Analyzed risk factors including genetic aberrations and smoking history.
Assessed overall survival of patients with second primary malignancies.
Included 1,476 patients with a median follow-up of 5.7 years.
Cumulative incidence of second primary malignancies was 8.8% at 5 years and 20% at 10 years.
Older age, Caucasian race, and smoking history were significant risk factors for developing second primary malignancies.