What question did this study set out to answer?

To assess the efficacy and safety of talquetamab bridging therapy prior to CAR T-cell infusion in patients with relapsed/refractory multiple myeloma.

December 8, 2025BloodOpen Access

Talquetamab bridging therapy for B-cell maturation antigen chimeric antigen receptor T-cell in Relapsed/Refractory multiple myeloma

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Authors

SSSara Scott ANAjay Nooka JKJonathan Kaufman

Discussion

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Implication

Evaluation shows talquetamab bridging therapy effectively improves treatment response in relapsed/refractory multiple myeloma, indicating manageable adverse effects.

Key Points

To assess the efficacy and safety of talquetamab bridging therapy prior to CAR T-cell infusion in patients with relapsed/refractory multiple myeloma.
Evaluated patients receiving talquetamab bridging therapy at Emory University Hospital.
Measured efficacy and safety outcomes including CRS, ICANS, and GPRC5D associated toxicities.
Used American Society for Transplantation and Cellular Therapy Consensus Grading for adverse effects.
25 patients received talquetamab with an overall response rate of 88%.
100% of patients reached a VGPR or better after cilta-cel infusion.
Reported adverse effects included dysgeusia and xerostomia, with manageable severity.

Cite This Study

Scott et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7f8 https://doi.org/10.1182/blood-2025-2811

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Implication

Evaluation shows talquetamab bridging therapy effectively improves treatment response in relapsed/refractory multiple myeloma, indicating manageable adverse effects.

Talquetamab bridging therapy for B-cell maturation antigen chimeric antigen receptor T-cell in Relapsed/Refractory multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

Talquetamab bridging therapy for B-cell maturation antigen chimeric antigen receptor T-cell in Relapsed/Refractory multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

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