What type of study is this?

This is a Human Clinical Trial study (also classified as: RCT).

What question did this study set out to answer?

To compare short- and mid-term outcomes of Ivor Lewis versus McKeown minimally invasive oesophagectomy in patients with mid-lower esophageal squamous cell carcinoma.

December 8, 2025Surgical EndoscopyOpen Access

Ivor Lewis minimally invasive oesophagectomy versus McKeown approach: short-term benefits and mid-term equivalence in a randomized trial for oesophageal squamous cell carcinoma

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To compare short- and mid-term outcomes of Ivor Lewis versus McKeown minimally invasive oesophagectomy in patients with mid-lower esophageal squamous cell carcinoma.
Prospective randomized controlled trial enrolling 272 patients with esophageal squamous cell carcinoma.
Randomization between Ivor Lewis (n=136) and McKeown (n=136) MIE groups at a 1:1 ratio.
Analysis of postoperative complications, operative parameters, and laboratory biomarkers.
Ivor Lewis group had significantly lower complication rates compared to McKeown.
Operative time was shorter in the Ivor Lewis group with a median of 210 minutes versus 285 minutes for McKeown.
Rates of anastomotic leak were 8.1% for Ivor Lewis and 16.9% for McKeown (p=0.03).
No significant difference in progression-free survival was observed between both groups.

Discussion

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Implication

Randomized trial compares short-term outcomes of Ivor Lewis and McKeown techniques in esophageal cancer, suggesting better early results with Ivor Lewis.

Cite This Study

An et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d80a https://doi.org/10.1007/s00464-025-12424-7

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Implication

Randomized trial compares short-term outcomes of Ivor Lewis and McKeown techniques in esophageal cancer, suggesting better early results with Ivor Lewis.

Ivor Lewis minimally invasive oesophagectomy versus McKeown approach: short-term benefits and mid-term equivalence in a randomized trial for oesophageal squamous cell carcinoma

Key Points

Discussion

Implication

Cite This Study

Ivor Lewis minimally invasive oesophagectomy versus McKeown approach: short-term benefits and mid-term equivalence in a randomized trial for oesophageal squamous cell carcinoma

Key Points

Discussion

Implication

Cite This Study

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