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December 8, 2025Blood

Epidemiological trends in leukemia and heart failure-associated mortality: A CDC wonder database analysis

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Authors

HSHafsa ShahidAQAhmad QaisarMYMuhammad Yasir

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Overview

Retrospective analysis reveals increasing co-morbid mortality in leukemia and heart failure, indicating the need for cardio-oncology strategies.

Key Points

  • This analysis aims to evaluate trends in mortality associated with leukemia and heart failure.
  • Retrospective analysis of CDC WONDER Multiple Cause of Death database
  • Inclusion of deaths with leukemia ICD-10 codes and heart failure as causes
  • Extraction of mortality counts and age-adjusted mortality rates
  • Determination of Annual Percent Changes using Joinpoint regression
  • 38,319 deaths from leukemia and heart failure recorded from 1999 to 2020
  • Overall age-adjusted mortality rate increased from 0.9 in 1999 to 1.0 in 2020
  • Higher mortality rates observed in Non-Hispanic Whites compared to other racial groups
  • Mortality rates declined among individuals aged 65-74 and 75-84 years, but increased in younger and older age cohorts

Cite This Study

Shahid et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d80fhttps://doi.org/10.1182/blood-2025-2824
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heart failure-related mortality in leukemia patients: A 26-year United States surveillance study (1999–2024).2026
  2. 2Trends in leukemia-related mortality with heart failure as a contributing cause among U.S. adults aged ≥55 years, 1999–2023.2026
  3. 3Burden of heart failure–related mortality among U.S. adults with leukemia (1999-2023).2026
  4. 4Trends in Mortality from Leukemia and Ischemic Heart Disease: A 22-Year Analysis in the U.S. (1999-2020)2025 · 6 citations
  5. 5A cardio-oncologic burden: Leukemia-associated arrhythmia mortality in the United States (1999-2023).2026