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December 8, 2025BloodOpen Access

HMGA1 chromatin regulator induces inflammatory signals and promotes atherogenesis in Tet2 mutant clonal hematopoiesis

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Authors

ZTZanshé ThompsonASAudrey-Ann SupremeMAMarios Arvanitis

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Overview

Experiments reveal HMGA1 drives atherosclerosis via inflammatory cytokines and macrophage activity in clonal hematopoiesis.

Key Points

  • This research investigates the role of HMGA1 in mediating inflammatory signals and atherogenesis in TET2 mutant clonal hematopoiesis.
  • Used a mouse model with biallelic deletion of low-density lipoprotein receptor gene
  • Conducted bone marrow transplantation from Tet2 mutant donors
  • Administered a high fat diet for 18 weeks
  • Performed single cell RNA sequencing and gene set enrichment analysis to uncover mechanisms
  • Decreased atheromatous plaque area in mice with HMGA1 deficiency compared to those with intact HMGA1
  • Reduced macrophage infiltration in diverse tissues of HMGA1-deficient mice
  • Lower levels of serum inflammatory cytokines linked to atherosclerosis in HMGA1 haploinsufficient mice
  • scRNAseq revealed HMGA1 activates pathways that drive inflammation and atherogenesis

Cite This Study

Thompson et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d828https://doi.org/10.1182/blood-2025-3177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HMGA1 chromatin regulators drive transcriptional networks involved in megakaryocyte expansion, fibrosis, and sensitivity to interferon signaling in JAK2-V617F MPN2025
  2. 2HMGA1 chromatin regulators drive transcriptional networks governing cell cycle progression, immune escape, and menin-inhibitor resistance in KMT2A-r Acute Myeloid Leukemia2025
  3. 3Clonal hematopoiesis drives T cell dysregulation and immune remodeling revealed by GWAS-based mendelian randomization and single-cell transcriptomics2025
  4. 4HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity2024 · 1 citations
  5. 5CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate Immunity2024