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December 8, 2025BloodOpen Access

17p loss in TP53-non-mutated myeloid neoplasms confers survival comparable to TP53-mutated disease

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Authors

FVFranceso VersinoEGEmmanuel GnanamanickamFAFrances Aldridge

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Overview

International study shows similar survival in TP53-non-mutated myeloid neoplasms with 17p loss and TP53-mutated cases, indicating a need for better classification.

Key Points

  • To define the frequency and prognostic impact of 17p loss in TP53-non-mutated myeloid neoplasms.
  • Evaluated patients with TP53-non-mutated myeloid neoplasms using cytogenetic analysis and next-generation sequencing.
  • Assessed 17p loss through karyotype data, FISH, and SNP array.
  • Compared overall survival of cases with 17p loss to TP53-mutated myeloid neoplasms.
  • Identified 85 cases with 17p loss, equating to 1% of TP53-non-mutated myeloid neoplasms.
  • Median overall survival for 17p loss cases was 10.2 months, similar to 8.7 months for TP53-mutated cases.
  • Complex karyotype occurred in 40% of cases, affecting survival outcomes minimally.

Cite This Study

Versino et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d84ehttps://doi.org/10.1182/blood-2025-3858
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced overall survival in TP53-mutated ccus is driven by prior cytotoxic exposure and cytopenia rather than leukemic progression2025
  2. 217p cytogenetic changes in TP53-mutated AML2025
  3. 3Genetic and Clinical Features in <i>TP53</i> ‐Mutated Patients With Myelodysplastic Neoplasms: A Retrospective Study Based on Next‐Generation Sequencing Data2026
  4. 4Real-world clinical characteristics and outcomes of patients with myelodysplastic syndrome with TP53 mutation2025
  5. 5Characteristics and prognostic implications of <i>TP53</i> mutations in Chinese patients with myelodysplastic syndromes2025 · 3 citations