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December 8, 2025Blood

Foreign antigen delivered to CLL B cells via membrane IgD leads to a distinct antigen processing pathway that allows antigen-specific T cell activation that is superior to membrane IgM delivery

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Authors

MCMartina CardilloMFMatthew J. FriedmanXYXiao‐Jie Yan

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Overview

Monoclonal antibodies targeting antigen processing via IgD improve T cell activation in CLL, indicating a novel therapeutic approach.

Key Points

  • This research aims to understand how antigen delivery via membrane IgD affects T cell activation in CLL.
  • Engineered murine monoclonal antibodies to target human IgM and IgD.
  • Studied antigen-specific T-cell activation and internalization in CLL cells using flow cytometry and confocal microscopy.
  • Compared T cell responses to IgM and IgD antigen delivery mechanisms in CLL and healthy donor samples.
  • Antigen delivery via IgD significantly improved T cell activation compared to IgM.
  • Higher CD69 and CD134 expression in T cells was observed with IgD delivery.
  • Distinct intracellular trafficking patterns were observed for IgM and IgD antigens.

Cite This Study

Cardillo et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d867https://doi.org/10.1182/blood-2025-3882
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