What question did this study set out to answer?

This study aims to evaluate the correlation between real-world progression-free survival and overall survival in patients with chronic lymphocytic leukemia.

December 8, 2025BloodOpen Access

Correlation between real-world (RW) progression-free survival (rwPFS) and overall survival (OS) among patients (Pts) with first-line (1L) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) receiving covalent bruton tyrosine kinase inhibitors (cBTKis) or B-cell lymphoma 2 inhibitors (BCL2is)

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Authors

JBJohn M. BurkeSarah Cannon ENEnrico De NigrisMSD (UK) Limited (United Kingdom)KAKathleen M. AguilarEADA Business School

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Implication

Observational cohort study shows strong correlation between progression-free survival and overall survival in chronic lymphocytic leukemia, suggesting rwPFS may serve as an early endpoint.

Key Points

This study aims to evaluate the correlation between real-world progression-free survival and overall survival in patients with chronic lymphocytic leukemia.
Retrospective observational cohort study
Included patients receiving first-line treatment with cBTKis or BCL2is
Used Kaplan-Meier methods to estimate OS and rwPFS
Calculated Kendall's tau correlation coefficients to evaluate the association between rwPFS and OS
Observed a strong correlation between rwPFS and OS with τ = 0.79
At 24 months, OS probability was 82.4% and rwPFS was 73.7% across the overall population
Higher risk of death in patients who progressed, with HRs of 2.328 and 2.617 in 3- and 6-month landmark analyses respectively

Cite This Study

Burke et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d86a https://doi.org/10.1182/blood-2025-3888

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Implication

Observational cohort study shows strong correlation between progression-free survival and overall survival in chronic lymphocytic leukemia, suggesting rwPFS may serve as an early endpoint.

Discussion

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Implication

Key Points

Cite This Study

Discussion

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Implication

Key Points

Cite This Study

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