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December 8, 2025Blood

Longitudinal and integrated analysis of oral and stool microbiome in allogeneic hematopoietic cell transplantation recipients.

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Authors

MGMonalisa GhoshDKDarren KingSCSung Won Choi

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Overview

Longitudinal analysis shows decreased oral and stool microbial diversity in patients, indicating effects on GVHD outcomes.

Key Points

  • To investigate the relationship between oral and fecal microbiome diversity and GVHD in allo-HCT recipients over time.
  • Longitudinal assessment of fecal and oral microbiome composition in 27 allo-HCT patients.
  • Microbiome samples collected at multiple time points pre- and post-transplantation.
  • Analysis of microbiome composition using 16S rRNA gene sequencing.
  • Decreased bacterial diversity observed at neutrophil count nadir in fecal and oral samples (p<0.01).
  • Persistence of reduced fecal diversity in patients who developed aGVHD (DI 2.00 vs 3.05; p<0.01).
  • Patients with gastrointestinal aGVHD showed enrichment of Enterobacteriaceae, while those without aGVHD had increased Lachnospiraceae.

Cite This Study

Ghosh et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d876https://doi.org/10.1182/blood-2025-4225
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Data from Oral and Gut Microbiome Alterations in Oral Chronic GVHD Disease: Results from Close Assessment and Testing for Chronic GVHD (CATCH Study)2024
  2. 2Oral and gut microbiome alterations in oral chronic graft-versus-host disease: results from Close Assessment and Testing for Chronic GVHD (CATCH study)2024 · 16 citations
  3. 3Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study2024 · 12 citations
  4. 4Early gut microbiome metabolites and diversity predict GVHD-free survival after allogeneic hematopoietic cell transplantation2026
  5. 5Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation2025