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December 8, 2025Blood

Sickle cell disease survival analysis at a large United States southern comprehensive sickle cell disease center: 1995 - 2022

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Authors

MCM. L. ChanceJLJeffrey D. LebensburgerHCHenry Carlton

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Overview

Retrospective cohort study reveals 96% survival in sickle cell anemia, indicating need for intervention improvements.

Key Points

  • To evaluate survival rates and causes of death among patients with sickle cell disease at UAB.
  • Conducted an IRB-approved retrospective cohort study of patients born between 1995-2002.
  • Reviewed medical records of deceased patients from UAB and its satellite clinics.
  • Categorized deaths between SCD-related and non-SCD-related; analyzed demographics and statistics.
  • Among 1358 patients, 31 deaths (2.2%) occurred; median age at death was 15 years.
  • Overall survival was 97.9% at 19 years and 96.0% at 25 years for the SCD cohort.
  • Patients with sickle cell anemia had a mortality rate of 3.3%, significantly higher than those with other genotypes (0.7%).

Cite This Study

Chance et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8adhttps://doi.org/10.1182/blood-2025-6225
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