What question did this study set out to answer?

This research aims to report updated mortality statistics among patients with sickle cell disease utilizing a longitudinal registry.

December 8, 2025BloodOpen Access

Mortality in sickle cell disease: A report from the grndad registry

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Authors

JSJohn J. StrouseDuke University JLJane A. LittleUniversity of North Carolina at Chapel Hill

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Implication

Longitudinal analysis reveals a mortality rate of 11.7 deaths per 1,000 person-years in sickle cell disease patients, indicating ongoing challenges in quality improvement.

Key Points

This research aims to report updated mortality statistics among patients with sickle cell disease utilizing a longitudinal registry.
Prospective longitudinal registry study with 5,198 patients providing demographic and clinical data.
Follow-up conducted over a mean of 3.1 years per patient, totaling 15,014 person-years.
Mortality rates calculated and analyzed across various demographics and disease types.
Overall mortality rate was 11.7 deaths per 1,000 person-years.
Mortality among pediatric patients was significantly lower than adults, at 1.3 per 1,000 versus 15.2 per 1,000.
Cardiac complications, sepsis, and renal complications were among the leading causes of death.

Cite This Study

Strouse et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9b6 https://doi.org/10.1182/blood-2025-2973

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Implication

Longitudinal analysis reveals a mortality rate of 11.7 deaths per 1,000 person-years in sickle cell disease patients, indicating ongoing challenges in quality improvement.

Mortality in sickle cell disease: A report from the grndad registry

Discussion

Member takes

Implication

Key Points

Cite This Study

Mortality in sickle cell disease: A report from the grndad registry

Discussion

Member takes

Implication

Key Points

Cite This Study

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