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December 8, 2025BloodOpen Access

Sickle cell disease in europe: A cross-border real-world data analysis from the radeep registry

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Authors

RCRaffaella ColombattiPBPaola BianchiAKAntonis Kattamis

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Overview

Cross-border analysis shows high disease burden and complications in sickle cell disease patients indicating need for improved care.

Key Points

  • To characterize the disease burden, clinical outcomes, and treatment patterns for sickle cell disease in Europe.
  • Cross-border real-world data analysis using the RADeep Registry.
  • Patient individual data collected from 3119 sickle cell disease patients across 80 centers in 7 countries.
  • Patients stratified by age, subdiagnosis, and genotype for analysis.
  • Majority of patients experienced vaso-occlusive crises, with chronic complications reported higher in sickle cell anemia.
  • Hydroxyurea prescribed to 72.1% of patients, increasing with age, especially in sickle cell disease.
  • Significant rates of avascular necrosis and retinopathy observed in adults, indicating severe chronic complications.

Cite This Study

Colombatti et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de41https://doi.org/10.1182/blood-2025-179
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Data validation and quality framework for building a european multimodal real-world dataset for clinical outcome research in sickle cell disease2025
  2. 2Thalassemia in europe: A cross-border real-world data analysis from the radeep registry2025
  3. 3Improvement of sickle cell disease care mitigates the healthcare utilization induced by increased prevalence: Experience of a tertiary pediatric center2025
  4. 4HbSC disease: Not as benign as you think2026
  5. 5Implementing patient-centered PROMs in sickle cell disease care: A european consensus approach2025