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December 8, 2025Blood

Thalassemia in europe: A cross-border real-world data analysis from the radeep registry

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Authors

PBPaola BianchiSTStella TamanaDCDaniela Cuzzubbo

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Overview

Cross-border analysis reveals clinical outcomes and healthcare resource utilization in Thalassemia patients, indicating underreporting of alpha-thalassemia.

Key Points

  • To characterize the disease burden and clinical outcomes of Thalassemia patients in Europe using the RADeep Registry data.
  • Prospective and longitudinal data collection from health care providers
  • Inclusion of patients with beta-thalassemia major and intermedia, and alpha-thalassemia/Hemoglobin H disease
  • Exclusion of patients who underwent hematopoietic stem cell transplantation or gene therapy before enrollment
  • A total of 900 Thalassemia patients were analyzed across 51 centers in Europe
  • The cohort comprised 81.3% beta-thalassemia major and 18.7% alpha-thalassemia patients
  • 62.1% of beta-thalassemia and 36.5% of alpha-thalassemia patients exhibited chronic organ damage

Cite This Study

Bianchi et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236dae1https://doi.org/10.1182/blood-2025-4696
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spanish registry of hemoglobinopathies and rare anemias (REHem-AR): demographics, complications, and management of patients with β-thalassemia2024 · 6 citations
  2. 2Revisiting morbidities and predictors in transfusion-dependent thalassemia: A cohort study over 10 years from the national registry of hemoglobinopathies in Türkiye2025
  3. 3High morbidity in adults with non-transfusion-dependent thalassemia referred to u.S. specialty centers2025
  4. 4Sickle cell disease in europe: A cross-border real-world data analysis from the radeep registry2025
  5. 5Beta‐Thalassemia in Spain: Results From the National Thalassemia Registry and Molecular Analysis of Patients With Transfusion‐Dependent Thalassemia2026