What question did this study set out to answer?

This study aims to assess morbidity trends and predictors in transfusion-dependent thalassemia patients over a decade.

December 8, 2025Blood

Revisiting morbidities and predictors in transfusion-dependent thalassemia: A cohort study over 10 years from the national registry of hemoglobinopathies in Türkiye

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Cohort study reports morbidity trends in transfusion-dependent thalassemia patients, highlighting risk factors and outcomes of treatment.

This study aims to assess morbidity trends and predictors in transfusion-dependent thalassemia patients over a decade.
Conducted a nationwide cohort study involving patients from 63 Thalassemia Centers in Türkiye.
Standardized clinical, laboratory, and imaging data collection using electronic medical records.
Analyzed patients aged over 10 years who received frequent red blood cell transfusions.
Evaluated risk factors affecting morbidity through logistic regression analysis.
54.5% of patients had at least one morbidity, with a significant association with splenectomy.
Endocrine and skeletal complications increased notably with age, reaching 51.3% and 65.4% respectively by the 4th decade.
Cardiovascular morbidities increased from 3% in the 2nd decade to 27.3% by the 5th decade.

Yozgat et al. (2025) studied this question.

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December 8, 2025Blood

View Full Paper

Ask AI

Bookmark

Authors

Cohort study reports morbidity trends in transfusion-dependent thalassemia patients, highlighting risk factors and outcomes of treatment.

This study aims to assess morbidity trends and predictors in transfusion-dependent thalassemia patients over a decade.
Conducted a nationwide cohort study involving patients from 63 Thalassemia Centers in Türkiye.
Standardized clinical, laboratory, and imaging data collection using electronic medical records.
Analyzed patients aged over 10 years who received frequent red blood cell transfusions.
Evaluated risk factors affecting morbidity through logistic regression analysis.
54.5% of patients had at least one morbidity, with a significant association with splenectomy.
Endocrine and skeletal complications increased notably with age, reaching 51.3% and 65.4% respectively by the 4th decade.
Cardiovascular morbidities increased from 3% in the 2nd decade to 27.3% by the 5th decade.

Yozgat et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark