What question did this study set out to answer?

This study aims to describe the clinical profiles and management gaps in adults with non-transfusion-dependent thalassemia.

June 20, 2026Blood AdvancesOpen Access

Delayed Recognition and Significant Morbidity in Adults with Non-Transfusion-Dependent Thalassemia

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Multi-institutional study uncovers significant morbidities in adults with non-transfusion-dependent thalassemia, indicating urgent management needs.

This study aims to describe the clinical profiles and management gaps in adults with non-transfusion-dependent thalassemia.
Multi-institutional study across three U.S. thalassemia centers
Identified 82 patients aged ≥18 years with non-transfusion-dependent thalassemia from 2013 to 2023
Collected data via manual chart review, including clinical history, laboratory tests, and imaging.
Median age at visit was 36.8 years, with 71% of liver MRIs showing hepatic iron >5 mg Fe/g dry weight
Only 24.4% of patients with liver iron content >5 mg Fe/g were on chelation at referral
49% of patients were recommended to start regular transfusions for symptomatic anemia or complications.

Cheng et al. (2026) studied this question.

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Multi-institutional study uncovers significant morbidities in adults with non-transfusion-dependent thalassemia, indicating urgent management needs.