Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

High morbidity in adults with non-transfusion-dependent thalassemia referred to u.S. specialty centers

View Full Paper
Ask AI
Bookmark
Share

Authors

ACAaron Cheng

Discussion

Loading...

Member takes

Overview

Multicenter analysis reveals prevalent complications and iron overload in adult NTDT patients, suggesting urgent need for improved referral practices.

Key Points

  • The study aimed to characterize clinical features of adults with non-transfusion-dependent thalassemia at referral to specialty centers in the U.S.
  • Multicenter cross-sectional study of adults referred to thalassemia centers in the U.S.
  • Patients aged >18 with a clinical diagnosis of non-transfusion-dependent thalassemia were included.
  • Patient charts were manually reviewed to gather demographics, genotype, lab values, and complications.
  • 82 adults with NTDT were identified; 55% with beta-thalassemia and 45% with alpha-thalassemia.
  • Nearly 50% of patients were recommended for chronic transfusion therapy upon evaluation despite NTDT diagnosis.
  • Common complications included pulmonary hypertension in 14% of beta-thalassemia patients and a history of venous thromboembolism in 13% of beta-thalassemia patients.

Cite This Study

Aaron Cheng (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d30ehttps://doi.org/10.1182/blood-2025-1141
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Delayed Recognition and Significant Morbidity in Adults with Non-Transfusion-Dependent Thalassemia2026 · 2 citations
  2. 2Revisiting morbidities and predictors in transfusion-dependent thalassemia: A  cohort study over 10 years from the national registry of hemoglobinopathies in Türkiye2025
  3. 3Evaluation of cardiac complications in transfusion-dependent thalassemia (TDT) and non-transfusion dependent thalassemia (NTDT) beta thalassemia patients2020 · 2 citations
  4. 4Endocrinopathies in adult Egyptian thalassemia patients, a cross-section study, single-center experience2025
  5. 5The Risk of Rapid Deterioration of Sepsis in the Patient with Non-Transfusion-Dependent Thalassemia: A Case Report.2025