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August 9, 2025

The Risk of Rapid Deterioration of Sepsis in the Patient with Non-Transfusion-Dependent Thalassemia: A Case Report.

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Authors

HGHuiling GanHainan Medical UniversityHYHang YuQingdao UniversityHHHidetaka HaraHainan Medical University

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Implication

Case report reveals rapid progression of sepsis and high mortality in patients with non-transfusion-dependent thalassemia, suggesting urgent clinical awareness.

Key Points

  • Rapid deterioration from sepsis is observed in non-transfusion-dependent thalassemia patients, leading to multiple organ dysfunction.
  • A 62-year-old male with thalassemia intermedia developed sepsis 43 hours after admission, highlighting urgency of diagnosis.
  • Comorbidities like iron overload and chronic anemia significantly worsen sepsis outcomes in thalassemia patients.
  • Increased awareness and proactive strategies in high-incidence areas may improve management and reduce mortality rates.

Cite This Study

Gan et al. (2025) studied this question.

synapsesocial.com/papers/689dfe97d61984b91e13bfdbhttps://doi.org/10.1080/03630269.2025.2543328
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular Function and Treatment in β-Thalassemia Major2013 · 395 citations
  2. 2Extensive systemic thrombo-embolism including intra-cardiac thrombosis mimicking an atrial myxoma in a patient with beta thalassaemia major – a case report2023 · 3 citations
  3. 3Severe Bacterial Infection in Transfusion-Dependent Patients with Thalassemia Major2003 · 81 citations
  4. 4Unstable and Thalassemic α Chain Hemoglobin Variants: A Cause of Hb H Disease and Thalassemia Intermedia2008 · 140 citations
  5. 5Changing patterns in the epidemiology of β‐thalassemia2020 · 334 citations