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December 8, 2025BloodOpen Access

Defective mitophagy of CD4+T cells in ITP via NAD+/SIRT1 reduction

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Authors

MXMengyu XiaoMZMengtong ZangLWLulu Wang

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Overview

Study uncovers mitophagy deficiency and NAD+/SIRT1 correlation in CD4+ T cells of ITP patients, suggesting therapeutic targets.

Key Points

  • The study investigates the mechanism of defective mitophagy in ITP CD4+ T cells through the NAD+/SIRT1 pathway.
  • Isolated CD4+ T cells from ITP patients and healthy donors.
  • Analyzed NAD+ levels using detection kits.
  • Assessed protein expression of SIRT1 via Western blotting.
  • Administered nicotinamide riboside and SIRT1 agonist in vitro; verified in vivo using an active ITP mouse model.
  • NAD+ content and SIRT1 expression were significantly reduced in ITP CD4+ T cells.
  • SIRT1 agonist improved mitophagy and mitochondrial function in vitro.
  • In vivo treatment accelerated platelet recovery and restored immune balance.
  • GSEA indicated upregulation of oxidative stress and DNA damage response pathways in ITP CD4+ T cells.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8f9https://doi.org/10.1182/blood-2025-1247
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