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December 8, 2025BloodOpen Access

Multi-proteomic analyses provide evidence for origin of a co-existing serum monoclonal gammopathy in CLL/MBL

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Authors

USUday Aditya SarkarBroad InstituteMMMariia MikhalevaUniversidade de BrasíliaNONatalie OnofriDana-Farber Cancer Institute

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Overview

A cohort study shows serum monoclonal gammopathy presence in CLL patients, suggesting implications for Ig production understanding.

Key Points

  • This research aims to determine if clonal CLL B cells release monoclonal immunoglobulins into the serum, indicating a possible link to concurrent monoclonal gammopathy.
  • Included 361 patients diagnosed with CLL or MBL.
  • Analyzed serum samples using MALDI-TOF mass spectrometry and other proteomic techniques.
  • Characterized clonotypic Ig heavy and light chains via sequencing and flow cytometry.
  • 21% of CLL/MBL patients showed serum monoclonal gammopathy through protein electrophoresis.
  • A match between leukemic Ig and serum Ig was found in 78.6% of CLL cases and 50% of MBL cases.
  • Detected immunoglobulin characteristics in cases without apparent monoclonal gammopathy, providing new insights.

Cite This Study

Sarkar et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d91fhttps://doi.org/10.1182/blood-2025-7408
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Also Consider

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  1. 1Mass spectrometry-based screening for monoclonal gammopathy in individuals undergoing physical examinations: Analyses of consecutive 15,068 cases in China2025
  2. 2Acquisition of CLL-like epigenetic and transcriptomic states in low-count MBL2025
  3. 3Mass Spectrometric Exploration of Biclonal Gammopathy: Insights from a Diagnostic Laboratory2025
  4. 4Development of a novel blood-based translational PCR screen for monoclonal B-cell lymphocytosis.2026
  5. 5Monoclonal gammopathy defines distinct clinical subsets in Chronic Lymphocytic Leukemia across therapeutic eras2025