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December 8, 2025BloodOpen Access

Multiparametric integration improves diagnostic categorisation of mature, non-CLL B-cell leukemias including atypical CLL - results from the prospective enable-NGS study

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Authors

KYKyoko YamaguchiENE NashMHMichael Hubank

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Overview

Prospective enable-NGS study shows improved diagnostic categorisation in non-CLL leukemias, indicating better treatment access.

Key Points

  • To assess the impact of multiparametric integration on the diagnostic categorisation of mature, non-CLL B-cell leukemias using next-generation sequencing.
  • Recruited 119 patients with unclassifiable LI B-NHL from 14 centres in the UK.
  • Utilized next-generation sequencing and other diagnostic methods at a 4-year follow-up.
  • Analyzed small variants, copy number variants, and structural variants.
  • Combined data allowed categorisation of 61% of patients into definitive lymphoma types.
  • Most common categories included marginal zone lymphoma (MZL) and atypical CLL (aCLL).
  • 4-year overall survival rates were 85%, 83%, and 92% in the overall cohort, MZL, and aCLL respectively.

Cite This Study

Yamaguchi et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d97dhttps://doi.org/10.1182/blood-2025-1753
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