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December 8, 2025BloodOpen Access

Magnetic resonance imaging maps spatiotemporal changes in bone marrow composition of murine JAKV617F models of myelofibrosis during progression and therapy

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Authors

YJYoungsoon JangDMDariya Malyarenko

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Overview

Multiparametric MRI reveals bone marrow phenotypes and efficacy in myelofibrosis, highlighting therapeutic resistance and monitoring.

Key Points

  • This research evaluates the use of MRI to monitor bone marrow composition changes in myelofibrosis, focusing on therapy response.
  • Used diffusion-weighted MRI to assess bone marrow phenotypes in Jak2+/V617F murine models over 10 weeks post-BMT.
  • Measured apparent diffusion coefficient (ADC) to quantify cellularity changes in the tibia marrow.
  • Assessed efficacy of multi-kinase inhibitor LP-182 in combination with Ruxolitinib on splenomegaly.
  • PRM indicated a ~20% increase in ADC between 5 and 10 weeks post-BMT in treated mice.
  • Combination therapy reduced spleen volume by ~35% compared to single treatments.
  • LP-182 maintained hematologic markers and reduced allele burden without observable toxicity.

Cite This Study

Jang et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d985https://doi.org/10.1182/blood-2025-2560
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