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December 8, 2025BloodOpen Access

Subtotal versus total splenectomy in children with sickle cell disease: Clinical outcomes and splenic function assessed by pocked red blood cell count

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Authors

VBValentine BrousseJBJoséphine BricePBPierre Buffet

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Overview

Retrospective analysis finds subtotal splenectomy increases postoperative complications in children, suggesting risks must be weighed against splenic function preservation.

Key Points

  • To compare effects of subtotal and total splenectomy on clinical outcomes and splenic function in children with sickle cell disease.
  • Single-center, retrospective study of 68 children with sickle cell disease who underwent splenectomy.
  • Clinical outcomes assessed within two years post-splenectomy.
  • Pocked red blood cell counts measured in a subgroup using differential interference contrast microscopy and imaging flow cytometry.
  • Subtotal splenectomy associated with younger patients and higher preoperative incidence of acute splenic sequestration.
  • Increased early postoperative morbidity including longer ICU stays and prevalence of fever in subtotal splenectomy group.
  • Higher rates of vaso-occlusive crises and acute chest syndrome in the subtotal splenectomy group during the first year.

Cite This Study

Brousse et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d997https://doi.org/10.1182/blood-2025-2953
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clearance of pathogenic erythrocytes is maintained despite spleen dysfunction in children with sickle cell disease2024 · 6 citations
  2. 2Long-term outcome after partial splenectomy compared to total splenectomy in children with spherocytosis2025
  3. 3Laparoscopic Subtotal Splenectomy in Pediatric Patients With Hematologic Disorders: A Case Series and Operative Technique.2025
  4. 4Pediatric splenectomy for hematologic disorders: two-decade experience and prophylactic cholecystectomy outcomes2025
  5. 5Comparative histological analysis of spleens in pediatric patients with hemolytic anemias: Insights into the pathophysiological mechanisms of spleen destruction in sickle cell anemia2024 · 5 citations