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December 8, 2025BloodOpen Access

Systematic intensification of red cell exchange with hydroxyurea decreased the transfusion burden in patients with sickle cell disease: A single-center retrospective cohort study

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Authors

YPYves PastoreBRBenjamin Rioux‐Massé

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Overview

Retrospective cohort study demonstrates reduced transfusion burden in sickle cell disease patients using hydroxyurea with red cell exchange, highlighting its safety and efficacy.

Key Points

  • This study evaluates the impact of hydroxyurea on transfusion burden in patients with sickle cell disease undergoing red cell exchange.
  • Single-center retrospective cohort study
  • Included adults with sickle cell disease receiving chronic red cell exchange and hydroxyurea
  • Measured transfusion burden and safety parameters before and after hydroxyurea initiation
  • Cumulative red blood cell units decreased from 81.7 to 76.2 units annually after hydroxyurea (p = 0.007)
  • No significant change in intervals between red cell exchange sessions (p = 0.1)
  • Adverse events included manageable cytopenias, with some instances of neutrophils dropping significantly (p = 0.003)

Cite This Study

Pastore et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d99chttps://doi.org/10.1182/blood-2025-2961
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world effectiveness and safety of hydroxyurea in adults with hemoglobin SC disease: A retrospective cohort study in Quebec, Canada2025
  2. 2Evaluation of hydroxyurea effect in patients with sickle cell disease: A prospective observational study2026
  3. 3Automated red blood cell exchange with a post‐procedure haematocrit targeted at 34% in the chronic management of sickle cell disease2024 · 6 citations
  4. 4Iron deficiency limits hydroxyurea-induced fetal hemoglobin and clinical efficacy in sickle cell disease2025
  5. 5Hydroxyurea (hydroxycarbamide) use in adults with haemoglobin <scp>SC</scp> disease: A real‐world study in Quebec2026