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June 28, 2026British Journal of HaematologyOpen Access

Hydroxyurea (hydroxycarbamide) use in adults with haemoglobin SC disease: A real‐world study in Quebec

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Authors

AGAlice GirardLCLaurianne CharetteMHMélissa Haouchine

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Overview

Retrospective cohort study finds hydroxyurea reduces pain crises in adults with haemoglobin SC disease, indicating effective treatment options.

Key Points

  • This study aims to evaluate the effectiveness and safety of hydroxyurea in reducing pain episodes in adults with haemoglobin SC disease.
  • Retrospective, single-centre, pre–post cohort study
  • Included patients who initiated hydroxyurea between January 2010 and July 2025
  • Effectiveness analysis required ≥12 months of pre-HU follow-up.
  • Hydroxyurea reduced mean vaso-occlusive crisis composite by 56% (0.57–0.25; Δ = −0.32 ± 0.84; 95% CI [−0.51, −0.13]; p = 0.0015)
  • Haematological adverse events were mostly mild: thrombocytopenia (32.7%), neutropenia (23.6%), leucopenia (20.9%)
  • Bilirubin elevations occurred in 10.9% of patients, all asymptomatic.

Cite This Study

Girard et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba2161bb0a67205c6221https://doi.org/10.1111/bjh.70622
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world effectiveness and safety of hydroxyurea in adults with hemoglobin SC disease: A retrospective cohort study in Quebec, Canada2025
  2. 2Hydroxyurea (hydroxycarbamide) in haemoglobin SC disease: Moving from therapeutic hesitation to evidence‐guided care2026
  3. 3Effectiveness of hydroxyurea (hydroxycarbamide) in a national sickle cell disease programme in Ghana.2025 · 2 citations
  4. 4Evaluation of hydroxyurea effect in patients with sickle cell disease: A prospective observational study2026
  5. 5The Indian experience with hydroxyurea in sickle cell disease: A 25-year systematic review2025 · 1 citations