What question did this study set out to answer?

To characterize neurodevelopmental alterations in adolescents with sickle cell disease (SCD) using neurocognitive testing and multimodal MRI.

December 8, 2025BloodOpen Access

Multimodal neuroimaging and neurocognitive assessment in adolescents with and without sickle cell disease

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Neurocognitive assessment reveals executive dysfunction in adolescents with sickle cell disease, indicating altered brain structure and perfusion.

To characterize neurodevelopmental alterations in adolescents with sickle cell disease (SCD) using neurocognitive testing and multimodal MRI.
Participants included African American adolescents aged 12-17 years with severe SCD and controls.
Assessment involved computerized neurocognitive evaluation, multimodal 3T MRI, and blood sampling during a single visit.
MRI protocols assessed cerebral perfusion, brain structure, metabolite levels, and white matter integrity using various imaging techniques.
Adolescents with SCD showed poorer executive function scores compared to controls (mean score: 89 vs. 109; p = 0.006).
Cerebral perfusion was elevated in patients in all regions assessed (p < 0.05).
Significant group differences were observed in metabolite levels, highlighting glutathione, N-acetylaspartate, and glycerophosphocholine.
Poorer executive function was linked with increased cerebral perfusion and reduced brain volumes in specific regions, including the hippocampus, caudate, and putamen.

Wilson et al. (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

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Authors

Neurocognitive assessment reveals executive dysfunction in adolescents with sickle cell disease, indicating altered brain structure and perfusion.

To characterize neurodevelopmental alterations in adolescents with sickle cell disease (SCD) using neurocognitive testing and multimodal MRI.
Participants included African American adolescents aged 12-17 years with severe SCD and controls.
Assessment involved computerized neurocognitive evaluation, multimodal 3T MRI, and blood sampling during a single visit.
MRI protocols assessed cerebral perfusion, brain structure, metabolite levels, and white matter integrity using various imaging techniques.
Adolescents with SCD showed poorer executive function scores compared to controls (mean score: 89 vs. 109; p = 0.006).
Cerebral perfusion was elevated in patients in all regions assessed (p < 0.05).
Significant group differences were observed in metabolite levels, highlighting glutathione, N-acetylaspartate, and glycerophosphocholine.
Poorer executive function was linked with increased cerebral perfusion and reduced brain volumes in specific regions, including the hippocampus, caudate, and putamen.

Wilson et al. (2025) studied this question.

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