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December 8, 2025BloodOpen Access

Mapping activated microglial density in individuals with sickle cell disease utilizing time-dependent diffusion-weighted MRI and correlation with cognitive performance

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Authors

KKKristine KarkoskaHHHyacinth Hyacinth

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Overview

Analysis shows activated microglial density correlates with cognitive deficits in sickle cell disease patients, indicating neuroinflammation's role.

Key Points

  • The study aims to investigate the relationship between activated microglial density and cognitive performance in individuals with sickle cell disease.
  • Enrolled individuals with sickle cell disease aged 18-45 years with higher risk genotypes
  • Conducted time-dependent diffusion-weighted MRI and the NIH Toolbox: Cognition Battery
  • Excluded those with overt stroke, neurological disorders, or chronic transfusions
  • Matched controls by race, age, sex, and socioeconomic status
  • Higher density of activated microglia found in anterior hippocampus and frontal gray matter of sickle cell disease group
  • Significant correlation identified between activated microglial density and cognitive performance
  • Both groups performed below the nationalized mean on the cognitive battery

Cite This Study

Karkoska et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4a8https://doi.org/10.1182/blood-2025-1185
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multimodal neuroimaging and neurocognitive assessment in adolescents with and without sickle cell disease2025
  2. 2Abstract TP073: Glymphatic Dysfunction Is Impaired In Sickle Cell Disease And Associated With Microstructural Damage And Slower Processing Speed2026
  3. 3Subclinical neurovascular injury and cognitive outcomes in adults with sickle cell disease: Prevalence and imaging correlates2025
  4. 4Description of neurocognition in adult sickle cell disease patients using the NIH toolbox2025
  5. 5Neuroanatomical Variations and Their Influence on Cognitive Functions2024