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December 8, 2025BloodOpen Access

Description of neurocognition in adult sickle cell disease patients using the NIH toolbox

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Authors

IRIris RahmanTCTerrell CoringDQDevona Quasie-woode

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Overview

Observational study reveals lower neurocognition in adult sickle cell disease patients, indicating the impact of anemia and acute chest syndrome.

Key Points

  • This research aims to describe neurocognitive performance in adults with sickle cell disease using the NIH toolbox.
  • Prospective observational study conducted at MedStar Washington Hospital Center from 2022-2025.
  • Sickle cell disease patients presenting with vaso-occlusive crisis were cognitively assessed at intervals.
  • Cognitive assessments were performed using the NIH toolbox focusing on various cognitive domains.
  • 100% of sickle cell disease patients scored below age-matched controls on cognitive tests.
  • Statistically significant lower scores associated with acute chest syndrome and hemoglobin levels below 7 mg/dL.
  • No significant correlation found between vaso-occlusive crisis frequency and neurocognitive scores.

Cite This Study

Rahman et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db05https://doi.org/10.1182/blood-2025-4716
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation Between VOC and Cognitive Function Using the NIH ToolBox in SCD2024
  2. 2Evaluating the efficacy of brief neurocognitive assessments in adults and adolescents with sickle cell disease2025
  3. 3Multimodal neuroimaging and neurocognitive assessment in adolescents with and without sickle cell disease2025
  4. 4Mapping activated microglial density in individuals with sickle cell disease utilizing time-dependent diffusion-weighted MRI and correlation with cognitive performance2025
  5. 5Electrophysiological and Psychological Correlates of Cognition in Adult Homozygous Sickle Cell Disease Patients2026