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December 8, 2025Blood

Evaluating the efficacy of brief neurocognitive assessments in adults and adolescents with sickle cell disease

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Authors

LGLisbel GonzalezJRJohn L. ReaganPMPatrick T. McGann

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Overview

Prospective evaluation of neurocognitive assessments in sickle cell disease indicates high detection of impairments.

Key Points

  • To identify effective neurocognitive screening strategies for adults and adolescents with sickle cell disease, aiming for timely referrals for comprehensive evaluations.
  • Participants recruited at Brown University Health Comprehensive Sickle Cell Clinic during routine visits or blood transfusions.
  • Three neurocognitive assessment tools administered: NIH Toolbox, Montreal Cognitive Assessment (MoCA), and RUDAS.
  • Statistical analyses conducted to evaluate the feasibility and effectiveness of screening tools, as well as associations with clinical factors.
  • 55% of participants identified with impairments via NIH Toolbox, 60% via MoCA, and 8% via RUDAS.
  • NIH Toolbox rated the most difficult but most useful by participants, indicating it may capture more deficits.
  • A total of 25 participants enrolled, with varying completion times for each assessment.

Cite This Study

Gonzalez et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2f4https://doi.org/10.1182/blood-2025-7963
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Description of neurocognition in adult sickle cell disease patients using the NIH toolbox2025
  2. 2A - 87 Exploring the Utility of the Montreal Cognitive Assessment to Identify Neurocognitive Deficits among Adult Patients with Sickle Cell Disease2024
  3. 3Multimodal neuroimaging and neurocognitive assessment in adolescents with and without sickle cell disease2025
  4. 4Correlation Between VOC and Cognitive Function Using the NIH ToolBox in SCD2024
  5. 5B - 102 Neurocognitive Functioning of Patients Diagnosed with Sickle Cell Disease in Low-to-Middle Income Countries2024