What question did this study set out to answer?

To explore the role of circulating tumor DNA in decision-making for patients with early-stage node-negative rectal cancer undergoing organ preservation strategies.

December 8, 2025JCO oncology advances.Open Access

Detection of Molecular Residual Disease by Circulating Tumor DNA in Early-Stage Node-Negative Rectal Cancers (CCTG CO.28) Using a Tumor-Informed Assay

View Full Paper

Ask AI

Bookmark

To explore the role of circulating tumor DNA in decision-making for patients with early-stage node-negative rectal cancer undergoing organ preservation strategies.
Conducted a phase II trial with 58 patients and analyzed ctDNA levels at different time points.
Patients received neoadjuvant chemotherapy involving infusional fluorouracil and oxaliplatin or capecitabine before surgery.
Blood samples collected prechemotherapy, postchemotherapy, and during follow-up for ctDNA analysis.
ctDNA detected in 24.5% of patients before chemotherapy, increasing with clinical T stage (P = .022).
Detection rate dropped to 6.7% after chemotherapy but before surgery (P = .024).
66.7% of patients with post-therapy ctDNA detected were recommended for total mesorectal excision due to lack of clinical response.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Phase II trial shows ctDNA detection improves clinical decision-making for organ preservation in rectal cancer.

Cite This Study

Loree et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9d8 https://doi.org/10.1200/oa-25-00055

View Full Paper

Ask AI

Bookmark

Detection of Molecular Residual Disease by Circulating Tumor DNA in Early-Stage Node-Negative Rectal Cancers (CCTG CO.28) Using a Tumor-Informed Assay

Key Points

Discussion

Implication

Cite This Study

Detection of Molecular Residual Disease by Circulating Tumor DNA in Early-Stage Node-Negative Rectal Cancers (CCTG CO.28) Using a Tumor-Informed Assay

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider