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December 8, 2025BloodOpen Access

Genomic characterization uncovers molecular subtypes in Mantle Cell Lymphoma

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Authors

PYPing YangQingdao UniversityXHXiaoyu HaoUniversity of Science and Technology of ChinaMZMingxia ZhuLiaocheng University

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Overview

Genomic characterization uncovers molecular subtypes in mantle cell lymphoma, suggesting precision therapy using BTK inhibitors for high-risk variants.

Key Points

  • This research aims to develop a prognostic subtyping system for mantle cell lymphoma (MCL) based on genetic mutations.
  • Analyzed formalin-fixed specimens from 104 newly diagnosed MCL patients using next-generation sequencing.
  • Identified prognostic subtypes through integrative clustering based on mutation profiles.
  • Conducted survival analyses using Kaplan-Meier and log-rank test, alongside multivariate Cox regression.
  • Classified MCL patients into three prognostic subtypes based on mutation profiles.
  • Subtype C3, with high-risk mutations like TP53, displayed the worst prognosis.
  • Treatment with ibrutinib significantly improved survival in high-risk subtype C3.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9e2https://doi.org/10.1182/blood-2025-3590
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials2024
  2. 2Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials2024 · 23 citations
  3. 3Heterogeneous TP53 mutation subtypes define prognostic classification in Mantle Cell Lymphoma2025
  4. 4Proteogenomic features define subtypes of mantle cell lymphoma2026 · 1 citations
  5. 5Mantle Cell Lymphoma: A Clinicopathologic Study of 80 Cases1997 · 501 citations