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December 8, 2025Blood0 citationsOpen Access

Fungal Infections After CAR-T Therapy and Their Implications for Patient Management

Fungal infections following chimeric antigen receptor T-cell (CAR-T) cell therapy: A retrospective case-control study in the south-central US

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Authors

MBMaryam BibiATAminah TayyabNPNiveditha Popuri

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Overview

Retrospective case-control study reveals invasive fungal infections in CAR-T patients, indicating high mortality risk despite prophylaxis.

Key Points

  • The study aims to examine the incidence and outcomes of fungal infections in patients receiving CAR-T therapy.
  • Retrospective case-control study conducted at the OU Health Stephenson Cancer Center.
  • Patient population included adults who received CAR-T therapy from September 2019 to July 2024.
  • Comparative analysis focused on clinical, laboratory data, and antifungal prophylaxis outcomes.
  • Among 94 patients receiving CAR-T therapy, 7 (7.4%) developed invasive fungal infections within a year.
  • Infections occurred despite antifungal prophylaxis, with high mortality observed (57.1% death rate).
  • Logistic regression analysis indicated significant risk factors including prior allogeneic HCT and prolonged neutropenia.
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Cite This Study

Bibi et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da4ehttps://doi.org/10.1182/blood-2025-2781
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