What does this research mean for the field?

Infections following CAR T-cell therapy occur in 39% of children, adolescents, and young adults, with 20% classified as severe. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to assess the prevalence and severity of infections following CAR T-cell therapy in children, adolescents, and young adults.

February 21, 2026Blood Immunology & Cellular TherapyOpen Access

Infections Following CAR-T therapies in Children, Adolescents, and Young Adults: A Systematic Review and Meta-Analysis

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Authors

MMMark MichaelHouston Methodist FMFady MishrikyRhode Island Department of Health KOKonstantinos OuranosHouston Methodist

Discussion

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Implication

Systematic review examines infection prevalence after CAR T-cell therapy in young patients, suggesting a need for better prevention strategies.

Key Points

The aim is to assess the prevalence and severity of infections following CAR T-cell therapy in children, adolescents, and young adults.
Conducted a systematic review and meta-analysis of existing studies.
Included patients aged ≤26 years receiving CAR T-cell therapy.
Searched databases like PubMed, Scopus, and Cochrane Library for relevant studies.
Utilized random-effects models to pool infection prevalence data.
Pooled prevalence of all-grade infections was found to be 39%.
Severe (grade ≥3) infections occurred in 20% of patients.
Infection-related mortality was reported at 2%.
Bacterial infections were the most common, making up 14% of infections.

Cite This Study

Michael et al. (2026) studied this question.

synapsesocial.com/papers/69994ba9873532290d01fd33 https://doi.org/10.1016/j.bict.2026.100040

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Implication

Systematic review examines infection prevalence after CAR T-cell therapy in young patients, suggesting a need for better prevention strategies.

Infections Following CAR-T therapies in Children, Adolescents, and Young Adults: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Infections Following CAR-T therapies in Children, Adolescents, and Young Adults: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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