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December 8, 2025BloodOpen Access

Clinicopathological characteristics and survival outcomes in adults with acute megakaryoblastic leukemia

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Authors

ÁBÁlex BatallerWJWei‐Ying Jen

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Overview

Retrospective review reveals response rate and survival outcomes in adult acute megakaryoblastic leukemia, indicating the need for better therapies.

Key Points

  • To analyze survival outcomes and define clinical characteristics in adults with acute megakaryoblastic leukemia.
  • Retrospective review of adult patients with AMKL treated from 2012 to 2024
  • Collected demographic, molecular, and cytogenetic data
  • Survival analysis performed using Kaplan-Meier method
  • Cytogenetic abnormalities classified per ELN 2022 guidelines
  • Mutational profiling conducted using next-generation sequencing.
  • Identified 28 patients with AMKL, with a median age of 59 years
  • Overall response rate was 60% in frontline and 30% in salvage settings
  • Significantly better overall survival in patients receiving allo-HSCT compared to chemotherapy alone
  • Common mutations included TET2 (57%), TP53 (53%) and hemoglobin levels were noted at 8.5 g/dl.

Cite This Study

Bataller et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da5dhttps://doi.org/10.1182/blood-2025-3405
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