What question did this study set out to answer?

To assess the effects of SNH-119014 on ATP production and oxidative stress in erythroid cells from β-thalassemia major patients.

December 8, 2025Blood

Snh-119014, a novel pyruvate kinase activator, enhances ATP production and reduces oxidative stress in erythroid cells from patients with β-thalassemia major

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Authors

QHQiulin HuangFirst Affiliated Hospital of University of South China

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Implication

Erythroid cells from patients with β-thalassemia major exhibit improved ATP levels and decreased oxidative stress with SNH-119014, implying new therapeutic potential.

Key Points

To assess the effects of SNH-119014 on ATP production and oxidative stress in erythroid cells from β-thalassemia major patients.
Compared PK activity of SNH-119014 and AG-348 in ex vivo models using erythroid cells from β-TM patients.
Isolated RBCs from 30 β-TM patients and treated with 10 μM of either compound for 4 hours.
Cultured CD34+ cells from β-TM bone marrow and differentiated them into erythroid precursors before treatment.
Both SNH-119014 and AG-348 increased PK activity (AC 50 values of 10.42 nM and 8.08 nM).
ATP levels increased by about 129% with SNH-119014 and 131% with AG-348 in RBCs.
ROS levels decreased by 30.8% with SNH-119014 and 26.1% with AG-348.

Cite This Study

Qiulin Huang (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dab5 https://doi.org/10.1182/blood-2025-4698

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Implication

Erythroid cells from patients with β-thalassemia major exhibit improved ATP levels and decreased oxidative stress with SNH-119014, implying new therapeutic potential.

Snh-119014, a novel pyruvate kinase activator, enhances ATP production and reduces oxidative stress in erythroid cells from patients with β-thalassemia major

Discussion

Member takes

Implication

Key Points

Cite This Study

Snh-119014, a novel pyruvate kinase activator, enhances ATP production and reduces oxidative stress in erythroid cells from patients with β-thalassemia major

Discussion

Member takes

Implication

Key Points

Cite This Study

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