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Evaluate the efficacy and safety of combining mycophenolate mofetil with prednisolone in wAIHA patients.

December 8, 2025BloodOpen Access

Prednisolone and mycophenolate mofetil as first-line therapy in warm autoimmune hemolytic anemia: A prospective pilot study

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Prospective pilot study shows safety and improved complete response rates in wAIHA patients using combination therapy.

Evaluate the efficacy and safety of combining mycophenolate mofetil with prednisolone in wAIHA patients.
Prospective single-centre study with newly diagnosed wAIHA patients aged ≥12 years.
Patients received prednisolone and mycophenolate mofetil as first-line therapy.
Primary outcomes included complete response rates, steroid use, and adverse events.
At 12 weeks, all patients (100%) achieved complete response.
Median time to achieve complete response was 4 weeks.
90% of patients remained relapse-free over a median follow-up of 14 months.

Ghosh et al. (2025) studied this question.

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