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December 8, 2025BloodOpen Access

Early weight gain predicts nutritional recovery in children with sickle cell anemia and severe acute malnutrition in Nigeria

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Authors

SAShehu U. AbdullahiHKHalima KabirKSKhadija A. Shamsu

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Overview

Extension of trial shows early weight gain improves nutritional recovery in children with sickle cell anemia and malnutrition, emphasizing treatment strategies.

Key Points

  • Assess predictors of nutritional recovery in children with sickle cell anemia and malnutrition after nutritional intervention.
  • 12-week extension of a multicenter randomized controlled feasibility trial
  • Participants included children aged 5-12 years with severe acute malnutrition
  • Intervention involved nutritional supplementation with ready-to-use therapeutic food (RUTF)
  • Follow-up at weeks 4, 8, and 12 of extension phase
  • 11% achieved a BMI z-score > -3.0 at week 24
  • Mean change in BMI z-score during extension was 0.13
  • Linear regression showed female sex linked to better treatment response
  • Higher 12-week BMI z-score associated with recovery at 24 weeks

Cite This Study

Abdullahi et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db0dhttps://doi.org/10.1182/blood-2025-4717
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early Body Mass Index z ‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study2026
  2. 2Adherence to ready-to-use therapeutic food in older children with sickle cell anaemia and severe acute malnutrition: a mixed-methods study in a low-income setting.2025 · 1 citations
  3. 3Rate and time of recovery and its predictors among children aged 6–59 months admitted to inpatient therapeutic feeding centers for the treatment of severe acute malnutrition in Sana’a, Yemen: a prospective cohort study2025 · 1 citations
  4. 4Combined nutrition education and vocational training for caregivers of children with sickle cell anemia and severe malnutrition: A feasibility study2025
  5. 5Factors Influencing Recovery and Mortality in Children with Severe Acute Malnutrition (SAM): Insights from a Therapeutic Feeding Program2025